SONICC is a brand new technology developed in collaboration with Purdue University that has unprecendented limits of detection for crystalline APIs. SONICC can detect 0.01% crystallinity whereas Powder X-Ray Defraction can only detect down to 1% crystallinity in a sample. This incredible increase in detection limit allows for earlier analysis of samples and the better understanding of formulations.
SONICC is able to create 3D reconstructions of powders and tablets allowing for the analysis of spatial distributions of crystalline material.
SONICC enables quantitation of crystallinity at least 2 orders of magnitude lower than PXRD. The selectivity of SONICC to chiral crystals allows one to detect down to 0.01% crystalline material in a solid dispersion. Comparison of XRD to SONICC for a griseofulvin sample as a function of time cryo-milled is shown here. Click the image to the left to see the results.
Image credit: Wanapun, et al. Anal. Chem. 2011, 83 (12), 4745-4751)
SONICC is a microscopy technique that allows one to visualize the distribution of crystalline material in the sample. SONICC can penetrate 400 μm into a sample also allowing for 3-D imaging of powders or tablets.