Your Crystallography Control Center

Rock Maker is a powerful yet easy-to-use software that manages the entire protein crystallization process for your
research team. Design experiments, set the automated imaging schedule, dispense with your liquid handler,
then examine and score the images. Got a hit? Use Rock Maker to
optimize conditions directly and build a new
experiment. Not sure which way to go? Use
the built-in analytics to discover promising
trends - then wash, rinse, and repeat.

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Your Crystallography Control Center

Rock Maker is a powerful yet easy-to-use software that manages the entire protein crystallization process for your research team. Design experiments, set the automated imaging schedule, dispense with your liquid handler, then examine and score the images. Got a hit? Use Rock Maker to optimize conditions directly and build a new experiment. Not sure which way to go? Use the built-in analytics to discover promising trends - then wash, rinse, and repeat.

Request Info


Powerful Experiment Design

  • Create “layers” that assign conditions to a single well or over several plates.
  • Vary conditions randomly with a Random Layer or systematically with a Grid Layer.
  • Work with one plate per experiment, or design an experiment with multiple plates.
  • Rock Maker is pre-loaded with the most commonly used commercially-available screens, and lets you design your own.
  • NEW! Use the Screen Experiment Wizard to simultaneously screen a protein against multiple screens – Rock Maker builds the individual experiments for you.

Two vies of the same drop containing Lysozyme crystals, one using visible light and one utilizing SONICC (Second Order Non-linear Imaging of Chiral Crystals).

Dynamic and Efficient Image Viewing

  • Visually inspect an entire plate at once with Rock Maker's thumbnail view. Toggle between imaging modes with a few mouse clicks.
  • Navigate and score your images using your keyboard and customizable scoring schemas.
  • View images in a slideshow for presentations or hands-off, full-screen image inspection.
  • Filter out empty drops, or view computer-scored positive and negative hits with Autoscoring (requires UV or SONICC imaging).
  • Zero-in on a Region of Interest in real-time with dynamic zoom using the scroll wheel on your mouse.
  • Annotate, draw on, and measure objects in your images with drawing tools.
  • View up to four drops simultaneously on the Compare tab. Compare different inspections of the same drop, or drops from different experiments.
  • Bring out details in UV, SONICC and FRAP images using the leveling histogram.
  • NEW! The image navigator’s Composite View shows you which drops at which wells have images with specific imaging settings from specific inspections – no more guessing which drops were imaged with UV.

Administer group-based accessibility and quotas to maximize your lab's productivity.

World-Class Support and Continuous User-Driven Improvements

  • Our support team continually receives the highest marks for customer satisfaction. Having trouble? Send an email or call – within an hour someone will work on your issue.
  • With an average of four software releases per year, your feedback and suggestions are developed, tested, and implemented year-round – which means the think-tank behind Rock Maker is a pool of crystallographers working at the leading pharmaceutical companies and research universities.

Organize plates, screens, ingredients, users, projects, experiments and more using the familiar Windows-like interface of the Tree.

Pre-populated Database

  • Rock Maker comes preconfigured with ingredients commonly used in crystallization experiments, and intelligence that allows you to vary the concentration or pH level of any ingredient without needing to input it again.
  • Keep your experiments organized with our efficient folder and file structure, using as many or as few levels as you want.
  • The database tracks more than just proteins. It conveniently bundles the buffers, ligands and other compounds you’re using to crystallize, making it easy to re-use your protein formulations.
  • Common commercially available screens are already entered and defined. Just drag-and-drop to select the one you need for your experiment.
  • Rock Maker's quick search puts nearly every piece of data in the system at your fingertips.

The Formulator can dispense a 100µL, 3 ingredient, 96-well grid in as little as 2 minutes.

Seamless Robot Integration

  • Rock Maker integrates with Rock Imager as well as other Formulatrix products such as the Formulator, Mantis, and NT8 liquid dispensers, so you can design, dispense, image, analyze, and optimize from one place.
  • An API is available for developers to integrate Rock Maker with other robots.

Built-In Data Analysis Tools

  • Use Search and Filter to mine your data to uncover trends based on a variety of parameters, helping you to continue your research efforts and focus in on conditions likely to grow bigger and better crystals. Or use the included Sample Searches to get started.
  • Create and manipulate charts to visualize your experiment results.
  • Print experiment reports for your lab notebooks.

Built-In Training with Rock Maker University

Rock Maker University provides tours of the major features and functions, and also provides tutorials that span the entire crystallography process to help you create what you need to create. For example, when you complete the "Make a Protein" tutorial, your efforts will result in a protein formulation you can use in any experiment -- no time is sacrificed while learning to use the software.

Rock Maker Web is an optional Rock Maker feature designed for labs that want to provide their users with the flexibility to view and score images from a web browser.
Changes to Rock Maker Web and Rock Maker are always in sync, including permissions set for any node on the tree.

Rock Maker Web is also tablet-friendly, supports common tablet gestures and is designed to let you do your work using your fingertips!

The server is located within your network so that your IT department can have full security control, meaning you can limit access to users on an Intranet or grant access to the server from anywhere on the Web.

If you got a problem playing the videos, please go to this link.

Rock Maker Computer Specifications:

  • SQL Server 2005 Workgroup or greater
  • .NET Framework 4.0
  • Windows XP / Server 2003 or greater
  • 100 MB hard drive space
  • 1 GB RAM
  • 1 GHz processor
  • 1024x768 resolution monitor
  • Networked file storage with minimum 500GB hard drive space (if used with an imager)

RM Web & Mobile Specifications:

  • IIS 5.1 or greater (comes with all supported Windows operating systems)
  • Internet access

Licensing Based On You:

Rock Maker is available in several different editions to meet your needs and budget.

  Rock Maker
Enterprise Edition
Rock Maker
Imaging Edition
Rock Maker
Experiment Design Edition
Design Experiment Only Screen Experiment
View / Score / Inspections  
User Groups and Security

  Average User Satisfaction Rate


Ajinomoto Althea, Inc. - WILLIAM WITTBOLD 8/5/2015 4:32 PM

"My supervisor is already impressed that our analysts have hit the ground running with the Rock Imager and have been generating data much faster. Our group workload is increasing and we would like to complement our Rock Imager and Formulator with the NT8 so move our crystallization projects along even faster, and also become a showcase lab for you!"

"…we’ve also doubled our throughput in a few short months thanks to Formulatrix!"

Major Pharmaceutical Company – anonymous review 10/20/2014 5:15 PM

Great product that is able to organize your lab and workflow. Increases productivity and allows for freedom of innovation.

Constellation Pharmaceuticals – Yong Tang 10/20/2014 5:15 PM

No additional feedback entered

IFSC - USP - São Paulo, Brazil – Maria Santos/João Possatto 8/28/2014 8:15 AM

Everything works well. We never had any trouble with both products. We use it for crystallization of proteins.

Leading Academic Lab – anonymous review 8/21/2014 1:38 PM

Crystallization screening is easy to setup with Rock Maker and image quality is very good. Technical support team responded to my request in a timely manner and solved all the problems I had.

GlaxoSmithKline - Liam Bonnette 4/26/2013 3:16 PM

RockMaker software is an evolving piece of software that becomes better with improvements implemented on a recurring basis. The Formulatrix software team is always eager to hear user recommendations and they certainly implement requested features. The software is very powerful and helps me complete crystal "hunting" quickly and efficiently.

Wang Laboratory at The Skirball institute - NYU Langone Medical Center 9/11/2014 7:29 PM

The software is very easy to use. Imaging conditions can easily be customized per experiment.

A leading academic lab – Anonymous Review 8/27/2014 8:01 PM

Fairly intuitive once you understand the program nomenclature. Very powerful way to design both 96 well and 24 well screens. Also very nicely catalogs and keeps track of images of crystals. The program does have a few bugs, though. Fortunately, they resolve when the program is restarted.

Major Pharmaceutical Company – anonymous review 4/30/2013 3:34 PM

In the single-drop report, it seems that only the image of the whole drop could be included. It'll be great if a zoom-in photo focused on one crystal could be used instead.

Major Pharmaceutical Company – anonymous review 10/20/2014 5:15 PM

It does a very good job of tracking experiments, but it's frustrating to use RockMaker, especially as a beginner - everything seems to require very precise, non-intuitive combinations of mousing and keystrokes. I think a lot more organized training would be helpful.


Additional Customer Applications


Institute for Molecular Bioscience -  The University of Queensland Logo

"We have been using the Rock Maker system for more than two years now. The Rock Maker system has enriched our discovery of crystallization conditions, we are especially pleased by the speed with which condition optimization experiments can be designed and built."

Gordon King, Ph.D.
University of Queesland

Genzyme Corporate logo

"I am very impressed with the innovative approach of Formulatrix and enjoy their products and service tremendously."

Ronnie Wei, Ph.D.

National Institutes of Health logo

"We are very happy with the Rock Imager 54 and Rock Maker from Formulatrix. They are easy to use and the quality of the images is superb. I highly recommend them to everyone who has robotic systems for crystallization setup. An automated crystal imaging system is essential, and Rock Imager is the best for the quality, capacity and versatility."

Wei Yang, Ph. D.
Laboratory of Molecular Biology NIDDK, NIH.

Novartis Pharmaceuticals Logo

Novartis signs a global deal with Formulatrix.

"We have been very pleased with the implementation of the Rock Maker platform at Novartis. Rock Maker has allowed us to improve our productivity using our existing crystallization robotic hardware. A key benefit has been integrating the entire crystallization process from experimental design through data management under Formulatrix' comprehensive, user-friendly software platform. We have also been happy with the continued support of Rock Maker and the commitment to meet our specific needs."

Travis Stams
Novartis Institutes for Biomedical Research

Pfizer Pharmaceuticals Logo

Pfizer signs a multi-site deal with Formulatrix.

"We are very satisfied with our Formulatrix Rock Maker software because it provides a user-friendly, experiment-like interface to our crystallization robotics. The way in which initial crystallization screening, follow-up optimization and imaging of results with Rock Imager are integrated makes it especially powerful and allows us to get the most from all our hardware."

Dennis E. Danley
Pfizer Groton Research & Development

Boehringer Ingelheim Pharmaceutical Logo

"We have chosen Rock Maker from Formulatrix as our software platform for automating crystallization screening because we believe that it offers the most complete, robust, easy-to-use, and viable long-term solution currently available on the market today. In addition, Formulatrix has researched and proposed various hardware platforms to allow for combination of their software platform with the best off-the-shelf hardware components. Based on the detailed product specifications we have received to date we are eager to begin using this product."

Dr. Sandy Farmer
Boehringer-Ingelheim Pharmaceuticals, Inc.

Max-Planck-Institut für molekulare Physiologie Logo

"We were looking for a software solution that not only allows for designing and tracking of crystallization experiments, but also operates liquid handling and imaging robots. As far as we know, Rock Maker is the only software on the market that solves this problem. In addition, Formulatrix builds an imaging robot that provides very good pictures of crystallization drops from all kinds of 96-well plates. We are very happy that Formulatrix was able to deliver a customized solution, and that we get immediate support."

Martin Kollmar
Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

Wyeth Pharmaceuticals Logo

Wyeth contracted Formulatrix to automate their protein crystallization process including experiment design, liquid dispensing, and image review. Formulatrix assessed their needs, worked with Wyeth to define the software solution, and successfully completed implementation of the project.

"We're very happy with the Formulatrix solution. It has increased our throughput, minimized human error, eliminated repetitive tasks, and helps us keep track of all experiment conditions."

Will Somers, Ph.D.

Exelixis Biopharmaceutical Logo

"We have found Rock Maker to be a comprehensive, robust and user-friendly system for managing our automated protein crystallization platform. The software was customized to meet our specific hardware and workflow needs, and is in constant use. We are also very happy with the ongoing product support from Formulatrix."

David J. Matthews, Ph.D.
Exelixis. Inc.