Merck R&D SONICC Utilities

Paul Reichert, Ph.D., Merck



This talk is taken from Protein Crystallization Automation Webinar Series. In the webinar, scientists from all over the world shared how our automation and software solutions have enhanced their protein crystallization workflow.


The ultimate imaging technology in visualizing protein crystals, Second Order Nonlinear Imaging of Chiral Crystals (SONICC) definitively finds crystals buried in precipitate or submicron crystals naked to the eye. Two powerful technologies, Second Harmonic Generation (SHG) and Ultraviolet Two-Photon Excited Fluorescence (UV-TPEF) are combined together in a completely automated imager to quickly image your high throughput crystallization plates and positively identify protein crystals.


SONICC is being utilized at Merck in a variety of experimental areas including macromolecular x-ray structural determination, small molecule crystallinity confirmation, biological drug delivery, and purification studies.

Paul reickert

About the Speaker:

Paul Reichert is a Research Fellow at Merck Research Labs in Kenilworth, NJ. He has been working with NASA and the Center for the Advancement of Science in Space (CASIS) to conduct his own set of zero-gravity experiments for Merck aboard the ISS since 1993. His current passion is the discovery and development of processes for crystalline monoclonal antibody (biologics) suspensions for drug delivery and manufacturing applications.