Rapid Automated Harvesting of Silver Nanoparticles using the µPulse TFF System


Silver nanoparticles, ranging from 1 to 100 nanometers in size, possess therapeutic and diagnostic capabilities and are being investigated as a safe means for targeted drug delivery. Biosynthesis offers a more sustainable and cost-effective method for their production, providing improved control over properties and potentially reducing toxicity levels. However, the subsequent purification process adds significant time and effort to the preparative workflow.
Traditional lab-scale harvesting techniques such as ultracentrifugation and ultrafiltration using dead-end centrifugal devices are labor-intensive, time-consuming, and suffer from scalability limitations.

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In this webinar, we will showcase the utilization of the µPulse-TFF system for harvesting silver nanoparticles, comparing it to ultracentrifugation and dead-end filtration methods. The µPulse system demonstrated faster processing of nanoparticles in a single step compared to ultracentrifugation and dead-end filtration, while also yielding comparable or higher quantities.
Unlike ultracentrifugation and dead-end filtration, the nanoparticles harvested using µPulse were smaller in size and more stable. In summary, our results highlight the µPulse system as a gentle, rapid, single-step, and user-friendly approach for harvesting silver nanoparticles.

Muhmmad Sajed - Application Scientist

About the Speaker:

Muhammad Sajed is currently working at FORMULATRIX as an application scientist for the µPULSE-TFF system and its applications in biological research. His areas of expertise include the production and purification of therapeutic enzymes, cell culturing, and industrial biotechnology. Before joining FORMULATRIX, he held positions as a research officer at the University of Punjab and as a lecturer at Lahore Garrison University.