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The µPulse® – TFF system by Formulatrix addresses this limitation with a miniaturized design by combining TFF with microfluidic pumping technology on a filter chip. This footprint reduces the hold-up volume to 0.65 mL, which is up to 100% recoverable.
Application Note
The µPulse filter chips can be cleaned in place and reused several times with negligible difference in filtration rates. We conclude that the use of the µPulse TFF system is a fast, scalable, and cost-effective approach for formulation of the purified recombinant proteins, and other biomolecules.
Application Note
The µPULSE, a lab-scale TFF system, offers customizable pressures for protein refolding, yielding faster and higher specific activity results compared to equilibrium dialysis. This applies broadly to buffer exchange scenarios.
Application Note
The µPulse system offers a significant advancement in lab-scale sample concentration and buffer exchange processes. Its integration of microfluidic technology with TFF enables faster, more efficient filtration and diafiltration, reducing sample loss and ensuring high recovery.