Active Pharmaceutical Ingredient

Characterization using SONICC®

SONICC (Second Order Nonlinear Imaging of Chiral Crystals) uses a femtosecond pulsed laser to exploit the frequency-doubling effect produced by the majority of Active Pharmaceutical Ingredients (APIs) and allows for 2-orders of magnitude improvement of sensitivity versus conventional techniques.

 

Unprecedented Crystallinity Sensitivity

 

SONICC was developed in collaboration with Purdue University that has unprecedented limits of detection for crystalline APIs. SONICC can detect 0.01% crystallinity whereas Powder X-Ray Diffraction can only detect down to 1% crystallinity in a sample. This incredible increase in detection limit allows for earlier analysis of samples and the better understanding of formulations.