NT8

®

Drop Setter for Protein Crystallization

Reliable Drop Setting: Reduce Costs + Increase Reproducibility

The NT8® - Drop Setter is a fast, nanoliter-volume liquid handler with drop dispensing capability, including setting drops for Lipidic Cubic Phase (LCP) experiments. 

  • Set up hanging drop, sitting drop, microbatch, in meso LCP drops, additive and seeding experiments

 

  • 8-tip head aspirates + dispenses drops from 10 nL to 1.5 μL

 

  • Reusable tips give you the option to dispose tips after each dispense or reuse them to reduce costs + environmental waste

 

  • Proportionally-Controlled Active Humidification prevents sample evaporation and increases experiment reproducibility
nt8 drop setter for lipidic cubic phase
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Testimonials

"As a crystallization robot capable of sitting or hanging screens and prepping expansion plates, the NT8 is fabulous. It is accurate, reliable and flexible. Notably, the water displacement mechanism and small tips allow for extremely low error rates at 100 nanoliter volumes. The tip washing module means that it requires almost no consumables and therefore costs nearly nothing to operate. Moreover, the machine is robust and forgiving even to the most careless or novice user. The NT8 is not just our crystallization robot, it is our most important liquid dispensing instrument."

Sirano Dhe-Paganon
Dana Farber Cancer Institute, HMS

"I believe that we have taken the NT8 to its limits. In our lab, there are times when the NT8 is running non-stop for multiple business days. The sitting drop plates we use have 3 wells to each reservoir, really testing the robot's ability to dispense in the correct location. As we approach 2 years with the NT8, I can say, with certainty, that the NT8 is a powerful robot. It dispenses its drops with high accuracy and precision. It is very versatile, being able to dispense its drops on all plates that are programmable. I am very pleased with the machine. My only complaint is the speed of the robot. Only 8 tip-heads are available for the low volume and high volumes tips. Nonetheless, I would recommend this robot over any other competitors."

Jonathan Alvarez
Althea, CMO

"The NT8 is a very versatile instrument that is fundamental to my research. It provides me with the flexibility to set up crystallisation plates as well aiding in the development of new methodologies. The low volume tips and its humidifier is a crucial aspect of the design that allows us to deal with highly viscous solutions and accurately dispense down to nanoliter volumes. The service team and engineers provide outstanding support and I would highly recommend this robot to other users."

Connie Darmanin
La Trobe University

Precise Drop Overlay for Seeding and Additive Experiments

The system's unmatched drop overlay precision allows you to add components to your drops, such as seeds and additives.  

 

The NT8’s flexible finger design contours to your plate for precise contact dispensing needed for setting up seeding and additive experiments.  

 

Simply, add your seed stock or additive to one of the three columns of the protein tray and run your protocol as if you are dispensing any other protein. The deck can accommodate up to 3 different microplates to increase your throughput.

Prevent Drop Evaporation and Increase Reproducibility

Proportionally-Controlled Active Humidification

The NT8 prevents sample evaporation with three powerful, fully-enclosed humidifiers that actively control humidity from ambient up to 95%. You can set humidity on/off manually or “set it and forget it” and let the NT8 do the work. The system has tight control of the humidity with a variance of only +/- 2.5%.

The NT8 Drop Setter can increase humidity from 60% to 85% in under 20 seconds. The humidifiers are positioned away from active samples so your drops are protected from condensation and buildup.

No need to mop up excess water around your plates.

Proportionally-Controlled
The system automatically regulates how many of the humidifiers are on to give a precise, even humidification throughout.  For example, when the humidification is within 5% of the target then only one humidifier will turn on.

 

Don't Worry about Running Out of Humidification
The NT8 uses a minute amount of water while maintaining a relative humidity of 85%. This coupled with a 5-gallon reservoir means that you won't run out of humidification during a dispense or need to refill the deionized water very often.

 

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