Formulatrix TFF Systems
Formulatrix has redefined ultrafiltration with automated, lab-scale TFF systems: the µPulse® and the aµtoPulse™. At the core of these compact instruments are our filter chips, which combine TFF with microfluidic pumping technology to miniaturize the entire fluid path. Each chip integrates fluid channels, diaphragm pumps, and regulatory valves into a single, self-contained unit, enabling rapid, gentle, and highly efficient concentration and diafiltration. This design minimizes hold-up volume, delivering up to 100% sample recovery, even for your most valuable biomolecules.
With advanced control and automation, our systems deliver reproducible, walk-away workflows. This allows researchers to streamline complex purification protocols, dedicating more time to their work while ensuring sample integrity.
µPulse – TFF System
The µPulse is an automated TFF system designed for the unique demands of lab-scale applications.
- Compact Design: About the size of a toaster, the µPulse is well-suited for research labs with limited bench space.
- Scale Precision: Process volumes from 100 mL to 1 mL and achieve up to 250 mL of buffer exchange without changing your setup.
- Maximum Recovery: Offers just 0.65 mL of hold-up volume, which is recoverable up to 100% with automated recovery options.
- Walk Away Operation: Monitor your run remotely. Simply set your parameters and let the µPulse automate the rest.
- Low Maintenance: All wetted components are disposable. The entire fluid path can be cleaned in place for re-use or discarded for single-use, ensuring reliable results.
aµtoPulse – High-Throughput TFF System
The aµtoPulse is an automated, high-throughput TFF system engineered for ultra-low volume workflows, offering the world’s lowest hold-up volume.
- High Parallel Throughput: Run up to 4 samples in parallel, each with independent pressure control. Handle volumes from 0.5 mL to 100 mL with endpoint precision as low as ±25 µL.
- Ultra-Low Hold-Up Volume: The aµtoPulse filter chips offer Industry-lowest hold-up volume of just 250 µL, enabling nearly complete sample recovery.
- Intelligent Workflow Automation: Save and reuse protocols for maximum reproducibility. From cleaning-in-place to sequential sample loading, the system automates every step.
- Flexible Buffer Management: Perform diafiltration with up to four external buffer reservoirs or on-deck conical tubes for maximum workflow adaptability.
- GMP-Ready Remote Access: Control and monitor runs via a secure, browser-based interface with data management that meets 21 CFR Part 11 standards for GMP.
Versatile for a Broad Range of Scientific Workflows
Efficiently process lipid nanoparticles, liposomes, and polymeric nanoparticles for drug delivery and therapeutic efficacy
Optimize the protein preparative workflow, enabling fast and gentle processes, including concentration, formulation, desalting, and refolding
Ensure gentle and efficient removal of small unconjugated molecules from a variety of crude biomolecular labeling reactions
Simplify in vitro synthesis of RNA, and linear or plasmid DNA, by efficient concentration and buffer exchange using our user-friendly system
Streamline the fast harvesting of cells, extracellular vesicles, enzymes, and Virus-Like Particles (VLPs) while ensuring high product yields and quality
Gently concentrate and exchange buffers for Adeno-associated Virus Vectors (AAVs), bacteriophages, and lentiviruses, preserving their structure for effective applications
Optimize the formulation of DNA, RNA, and polysaccharide vaccines for optimal, stable, and cost-efficient results