Planning and Executing Massively Combinatorial Phenotypic Assays

Presenters: Adam Dama and Dr. Paul Jensen, University of Illinois at Urbana-Champaign



The complexity of combinatorial screens explodes as the number of reagents increases. This talk addresses the challenges of planning experiments with up to 50 individually dispensed ingredients per well. The heart of our system is a new software package that automates the planning of complex liquid handling operations. We demonstrate combinatorial assays on the MANTIS® can detect metabolic interactions in bacteria with complex growth requirements.


About the Presenters

Adam Dama and Dr. Paul Jensen lead the Deep Phenotyping project at the University of Illinois at Urbana-Champaign. Adam is an automation software engineering and Paul is an assistant professor in the Department of Bioengineering and the Carl R. Woese Institute for Genomic Biology.