MANTIS® Liquid Handler

MANTIS® Liquid Handler

Small, Versatile, Precise

More Than a Reagent Dispenser

While traditional hand-held pipettes, or larger automated liquid handlers greatly deteriorate in accuracy and precision below 2 µL volumes, the MANTIS® automated liquid handler prevails in Efficiency, Reproducibility and Versatility.

Broad Range of Applications

 Assay Development and Design of Experiment (DoE)
 Next Generation Sequencing (NGS) - Library Preparation
 Polymerase Chain-reaction (PCR) Workflows - Real-time and Digital
 Enzyme-Linked Immunosorbent Assays (ELISA)
 Cell Culture and Bead-Based Assays



  • Efficient:  Miniaturize reactions, scale-up through-put, save on reagents and remove pipette tip cost.
  • Reproducible:   Dispense volumes down to 100nL at CV < 3%
  • Versatile:   Easily dispense and normalize reagents and cell culture assays

Overview of the MANTIS®

The MANTIS automated liquid handler is the easy and affordable solution to quickly increase the reproducibility and quality of your research as well as throughput and efficiency of your laboratory. The diaphragm-based chip design is liquid class compatible, easily dispensing aqueous and organic solutions. Additionally, the MANTIS will dispense in any SBS template from 6 to 1536 well plates, and can be easily programmed to dispense to custom designs as needed.

Key Features
  • High Precision
  • Low Volume Dispensing
  • Minimize Reagent Waste
  • Speed and Throughput
  • Import CSV Templates
  • Integrate with External Systems
  • Micro-diaphragm Technology
  • RFID Sample use tracking
  • Small foot print
  • Intuitive User Interface (UI)
  • Reagent Compatible
    (Mastermix, beads, buffer 70% glycerol, DMSO, etc)
Key Features
  • High Precision
  • Low Volume Dispensing
  • Minimize Reagent Waste
  • Speed and Throughput
  • Import CSV Templates
  • Integrate with External Systems
  • Micro-diaphragm Technology
  • RFID Sample use tracking
  • Small foot print
  • Intuitive User Interface (UI)
  • Reagent Compatible
    (Mastermix, beads, buffer 70% glycerol, DMSO, etc)

Enhance Laboratory Efficiency

Efficient research means that reagent dead volumes, tip consumption, and reaction volumes are minimized.  

The MANTIS liquid handler dispenses volumes from 100 nL to 100s of mL allowing researchers to commonly run 2-5 µL reaction volumes in genomics and screening workflows.

To minimize dead volume, reagents plug directly into the microfluidic chip. Dead volumes are further reduced to just 6 μL by using pipette tips as reagent reservoirs, making the Mantis ideal for dispensing even the most precious reagents.

Normalize Your Assay Plate, Quickly and Easily

  • The MANTIS software automatically calculates the normalization values for you.
  • The Continuous Flow (CF) chip bulk dispenses at >600 µL/sec, therefore, quickly normalizing each sample tube, well, and plate.

Dispense Beads and Cells with Ease

Magnetic beads are an efficient means for extracting and purifying nucleic acids. Conventional pipetting may result in the non-uniform dispensing of mag beads, leading to a lack of reproducibility. The ability of the MANTIS to precisely dispense high viscosity liquids allows uniform dosing of beads reducing operating costs and plastic waste.

Cells can be extremely sensitive, requiring additional care during handling, making the scalability of assays very challenging. The dispensing action of the MANTIS is gentle enough to dispense even the most delicate cells, such as primary neurons, while maintaining cell viability.

Use of Microfluidic Technology in MANTIS

At the core of our dispensers is patented microdiaphragm pump that meters and dispenses discrete volumes of liquid. This valve cluster can fill and dispense as fast as 10 times per second (exact speed depends on specific product). This proven technology is both incredibly precise and viscosity independent.

Highly Reproducible Data

Since liquid handling imprecision impacts experimental reproducibility, researchers consider CVs to be a vital factor when considering the automation of their research. 

At the core of the MANTIS' microfluidic dispensing chip is a valve cluster that measures and dispenses discrete volumes of liquid. This valve cluster has two micro-diaphragms (select either 100 nL and 500 nL or 1 μL and 5 μL) that can fill and dispense as rapidly as 10 times per second.

Low Volume ChipCV*
0.1 μL1.4%
0.5 μL0.5%
1 μL0.4%
High Volume ChipCV*
1 μL0.8%
5 μL1.1%
10 μL0.5%
25 μL0.4%
Continuous Flow Chip CV* 
25 μL0.3%
50 μL0.4%
100 μL0.3%
200 μL0.2%

* = The coefficient of variation (CV) is the average of three independent microfluidic Chip readings.

Versatility for Any and All Labs

The MANTIS dispenses any reagent efficiently and reproducibly regardless of volume, viscosity, temperature, concentration, and research  experience.  It is no wonder that every year, more and more researchers discover and obtain the MANTIS for dispensing reagents as a part of their diverse set of scientific workflows.

Miniaturize your cDNA synthesis and library preparation reactions, even with limited starting material.

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Gentle and even distribution of suspension, adherent and 3D cell cultures

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Enhance the cost-effectiveness
of any qPCR plate preparation workflow.

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Simplify the evolution from assay design to drug discovery.

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Maximize biomarker assay performance and minimize cost by reducing dead volume and reaction volumes without sacrificing the quality of experimental results.

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MANTIS® ROI Calculator

Determine a Return on Investment for the MANTIS system vs pipetting with disposable tips. Every lab is uniquely operated and, therefore, return on investment calculators are only as good as the information entered.


The cost of the MANTIS will be recouped* in pipette tip savings in

Switching to non-contact dispensing could also prevent

0 Kg of Plastic

From being generated and sent to waste each year**
* Based on the typical cost of MANTIS system, this ROI calculator is for illustration purposes only.
** Based on the weight of tips and rack. For 96 racked, sealed, PCR-grade generic-brand filtered 200 µL pipette tips.

User Account Management System

The MANTIS software allows seamless operation in regulatory environments  including controlling user access and tracking user history. Our user management system will help you run your MANTIS dispenser in GLP, 21 CFR Part 11, or other regulatory environments by controlling user permissions and storing an official audit trail for your records.

Here are some key benefits of the MANTIS 21 CFR Part 11 "capable" software:

User Account Management

  • Restrict user access and instrument control by locally defined permission levels
  • Lock users after failed login attempts
  • Set and manage password requirements
  • Archive old users, keep all user records

Secure Audit Trail Logging

  • Date and time stamped user-action and instrument action records
  • Full instrument and user-action electronic records are stored in a secure database
  • Export log files to password protected PDFs
  • Selectively manage log elements included in your audit trails
  • Audit trails maintained for the lifetime of the instrument