The Next Generation in Crystallization Imaging


Store More Plates in a Smaller Space

ROCK IMAGER 360 (RI360) is an automated imaging system specifically designed for protein crystallization experiments. This easy-to-use solution carefully incubates and captures superior-quality images of up to 364 microplates in a compact benchtop unit.

Key Features:

  • Intelligent imaging and superior optics provide industry-leading image quality
  • Patented plate storage and retrieval solution with a capacity for up to 364 plates
  • Compatible with SBS-sized microplates and SBS-sized thin glass lipidic cubic phase (LCP) plates
  • Precise incubation chamber temperature control from 30°C down to 4°C (chiller option is needed)
  • Browser-based software allows users to access the program from any computer within a local intranet
  • Know the status of your instrument instantly with a color-coded LED indication system
  • Seamless integration with ROCK MAKER® Crystallization Software

Systems You Can Trust

Over 15 Years of Imaging Excellence

Used worldwide by the top 25 pharmaceutical companies and renowned academic centers.


Image Quality Second to None

Optimized Optics

Every imaging technology is precisely optimized for crystal clear images.


Increase Your Throughput

Automation Designed for Speed

Image entire 96-well plates in only 3 minutes and incubate up to 364 plates.

Store More Plates in a Smaller Space

The RI360 features a patented plate storage and retrieval solution with a capacity for up to 364 plates in a compact benchtop footprint. This innovative design allows users to incubate more experiment plates than ever in the same footprint as previous ROCK IMAGER models. Choose from a variety of plate capacity options to fit your lab’s unique size and budget. The system grows with your lab as you can unlock more plate capacity as your throughput needs expand.

Play Video
RI 360 Flat Front Chil.2721 jp (1)

ROCK IMAGER 360 with Chiller

Grow Your Crystals at Your Desired Temperature

The RI360 provides precise temperature control ranging from 30°C down to 4°C through two cooling options:


  • Peltier-cooled: maintain a temperature ranging from 4°C below and 7°C above ambient


  • Chiller-cooled: regulate the incubation temperature from 4°C to 30°C, temperature is continuously monitored and maintained to within ±1°C
RI 360 Flat Front Chil.2721 jp (1)

ROCK IMAGER 360 with Chiller

Intuitive, Browser-based Software Designed Specifically for RI360

The RI360 comes with user-friendly, browser-based software that allows users to access the program from any computer within the local intranet. The modern software interface enhances usability and adds flexibility. The system dashboard provides a concise overview of storage space, hardware status, storage temperature, and various other parameters at a glance. The simplified user interface allows users to initiate incubation and set up an imaging schedule with a single click. The software offers a unique history feature for users to review previous imaging events.

Intuitive, Web-based Software

Intuitive, Web-based Software

See Every Detail of Your Drops with Superior Imaging Optics

Drop View
UV Crystals (1)


  • 5.0-megapixel, 2/3’’ color CMOS camera 
  • Captures high-quality images at up to 35 frames per sec



  • 12x-motorized zoom optics with less than 1 μm feature resolution project sharp, high-contrast images to the camera and allows small-feature zooming



  • A Köhler light source with a motorized condenser provides high-contrast images with no sample heating and a reliable drop location 
  • Motorized top and bottom polarizers

Highest Resolution Visible Light Imaging

Fixed Objective Option

Two objectives are available for imaging protein drops. The large field of view objective is used for locating drops with two high magnification objectives available for high-resolution imaging. The software automatically determines the best objective to use based on the size of the drop.


Continuous Zoom Optics

Infinite zoom values are available up to 12x magnification, allowing you to zoom in exactly to drop sizes and Regions of Interest (ROI).

Detect Crystals with Ultraviolet Imaging (Optional)

Protein crystallization drops are illuminated with ultraviolet (UV) light, and the fluorescence generated from aromatic amino acids like tryptophan is detected to create an image. If no fluorescence is detected within a crystal, then it lacks enough aromatic amino acids to produce a signal and is likely not a protein.


The UV imaging option is built into ROCK IMAGER with all several automated features, including automated imaging, extended focus imaging (EFI), and regions of interest (ROIs) that can help you see your crystals better.


The ROCK IMAGER UV imaging solution uses 100% UV-optimized components: UV-grade optics, a UV-sensitive camera, and UV lighting. This optimization is critical for achieving the best image quality and fastest imaging speed possible.

Find Protein-Protein Complexes With Multi-Fluorescence Imaging (Optional)

With MFI, you can now differentiate between crystals of a protein-protein complex and crystals of just one protein. Simply, label the two proteins, or subunits, prior to crystallization with two different amine-reactive dyes and then image your drop at the two corresponding wavelengths. Crystals that fluoresce at both wavelengths are protein-protein complexes, whereas those that fluoresce at only one wavelength are of a single protein.

protein-protein complexes - multi-fluorescence imaging
Multi-Fluorescence Imaging

Bovine pancreatic trypsin inhibitor (BPTI) labeled with Fluorescein and trypsin labeled with Texas Red.

Crystals fluoresce at both wavelengths indicating that they are the BPTI-trypsin complex.1