Protein Crystallization

Increase Throughput + Reproducibility

Trusted Worldwide by Labs of All Sizes

Our protein crystallization solutions are trusted by hundreds of laboratories worldwide, including at the top 10 leading pharmaceutical companies and at academic research institutes from around the globe.

Our clients come from a broad range of scientific studies and backgrounds. We have flexible automation and software solutions to fit your budget and workflow, regardless of lab size.

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Build Protein Crystallization Screens with Ease

The Formulator Screen Builder is a next-generation liquid handler designed specifically for protein crystallography. The system uses patented microfluidic technology to dispense up to 34 different ingredients. A 96-nozzle dispensing chip can dispense any volume of any ingredient of any viscosity into any well.

The patented microdiaphragm pumps dispense volumes from 200 nl and up into any microplate, even deep well blocks and non-SBS VDX/Linbro plates

Integrated barcode scanner automatically loads experiment and ingredient data while bottle sensors automatically know where ingredients are located

Reduce your lab’s costs and environmental impact, as no consumables are needed

Closed ingredient containers prevent evaporation, contamination, and noxious fumes from escaping

formulator protein crystallography screen builder

Learn More About the Formulator

Testimonials

"As a crystallization robot capable of sitting or hanging screens and prepping expansion plates, the NT8 is fabulous. It is accurate, reliable and flexible. Notably, the water displacement mechanism and small tips allow for extremely low error rates at 100 nanoliter volumes. The tip washing module means that it requires almost no consumables and therefore costs nearly nothing to operate. Moreover, the machine is robust and forgiving even to the most careless or novice user. The NT8 is not just our crystallization robot, it is our most important liquid dispensing instrument."

Sirano Dhe-Paganon

Dana Farber Cancer Institute, HMS

We have had our ROCK IMAGER 1000 for nearly 2 years and have setup and imaged >7000 plates in that time. The system has performed very reliably over that span from a mechanical standpoint and the associated Rock Maker software has made tracking, viewing and organizing our many projects simple and easy. The seamless integration of our Formulatrix Formulator with the imaging system has allowed us to carry out optimizations in a high throughput manner as well. Just as important is that the service and support have been excellent, with most issues dealt with remotely and new customer-driven features added at regular intervals.

Rafael Toro

Albert Einstein School of Medicine

"I believe that we have taken the NT8 to its limits. In our lab, there are times when the NT8 is running non-stop for multiple business days. The sitting drop plates we use have 3 wells to each reservoir, really testing the robot's ability to dispense in the correct location. As we approach 2 years with the NT8, I can say, with certainty, that the NT8 is a powerful robot. It dispenses its drops with high accuracy and precision. It is very versatile, being able to dispense its drops on all plates that are programmable. I am very pleased with the machine. My only complaint is the speed of the robot. Only 8 tip-heads are available for the low volume and high volumes tips. Nonetheless, I would recommend this robot over any other competitors."

Jonathan Alvarez

Althea, CMO

"The NT8 is a very versatile instrument that is fundamental to my research. It provides me with the flexibility to set up crystallisation plates as well aiding in the development of new methodologies. The low volume tips and its humidifier is a crucial aspect of the design that allows us to deal with highly viscous solutions and accurately dispense down to nanoliter volumes. The service team and engineers provide outstanding support and I would highly recommend this robot to other users."

Connie Darmanin

La Trobe University

Publications

Citations: 853 Application: Protein Crystallization

Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library

Lennartz et al., 2025 |Structural Biology |Link

Severe acute respiratory syndrome coronavirus SARS-CoV- continues to threaten global health This underpins the need for novel therapeutics against this virus Nonstructural protein Nsp of SARS-CoV- is a multifunctional protein with an essential role in viral replication As such it presents itself as an attractive target for drug discovery Here ...More |

Structural and Functional Characterization of Encapsulin-Targeted Double Ferritin Fold Ferroxidases

Anuchina et al., 2025 |Preprint |Link

Ferritins are a widespread family of proteins involved in iron homeostasis While classic ferritins consist of four -helices and form -meric nanocages related ferritin-like proteins display other types of assemblies and sometimes lack any iron storage capacity Here by analyzing the available genomic data we identify a family of double ...More |

Combining crystallographic fragment screening, algorithmic merging and digitized chemical synthesis efficiently yields scaffolds that target diverse NCS-1 protein-protein interactions implicated in neurological disorders

Muñoz-Reyes et al., 2025 |Preprint |Link

Efficient drug discovery relies on workflows that integrate structural insights with rapid and cost-effective exploration of chemical space Here we present a data-driven fragment-based lead discovery approach to target Neuronal Calcium Sensor NCS- protein-protein interactions PPIs This study represents a complete implementation of a single high-value design-make-test-analyze cycle that directly ...More |

A third type of PETase from the marine Halopseudomonas lineage

Turak et al., 2025 |Protein Science |Link

The enzymatic degradation of polyethylene terephthalate PET offers a sustainable solution for PET recycling Over the past two decades more than PETases have been characterized primarily exhibiting similar sequences and structures Here we report new PET-degrading hydrolases including HaloPETase from the marine Halopseudomonas lineage thereby extending the narrow sequence space ...More |

Impact of 2′-deoxyribo-purine substrates on nonenzymatic RNA template-directed primer extension

Fang et al., 2025 |Preprint |Link

The composition of the primordial genetic material remains uncertain Studies of duplex structure and stability and of nonenzymatic template copying chemistry provide insight into the viability of potentially primordial genetic polymers Recent work suggests that - deoxyribo-purine nucleotides may have been generated together with ribonucleotides on the early Earth Since ...More |

Protein Crystallization

Increase Throughput + Reproducibility

Automate Your Protein Crystallization Workflow

Trusted Worldwide by Labs of All Sizes

Reliable + Reproducible Protein Drop Setting

Build Protein Crystallization Screens with Ease

Find the Optimal Conditions for LCP Crystal Growth...

Without Waiting on Your Crystals.

Learn More About Your Protein Drops with Crystal Clear Imaging

Remove the Guesswork.

SONICC Finds Crystals that Other Technologies Cannot.