FLO i8® PD

FLO i8® PD

General Purpose Liquid Handler

An 8-channel general purpose liquid handler combining positive displacement pipetting with non-contact dispensing engineered to handle any viscosity liquid without manual calibration or liquid class programming.

FLOi8PD.391 (1)

Volume Range

Min: 0.2 µL

Max: 1000 µL

Technology

Positive

Displacement

Precision

CV <5%

@ 0.5 µL

Save Time and Costs with Non-Contact Droplet Control

The FLO i8 PD features non-contact droplet dispensing, enabling precise aliquoting down to 200 nL. This innovative system enables miniaturization, cuts tip costs, and streamlines workflows. Combined with its liquid class-agnostic positive displacement pipetting, the system effortlessly handles a wide range of liquids, including viscous and volatile types, delivering rapid and reliable results with minimal consumable use.

FLO i8 PD Liquid Handler - Hardware Overview

Overview of the FLO i8 PD

Key Features

  • 8 fully independent positive displacement channels
  • Non-contact droplet dispensing
  • Wide volume range (200 nL - 1000 µL)
  • Intuitive software
  • Liquid Class Agnostic
  • Intelligent liquid-level detection and tracking
  • Precise and accurate transfers
  • Smooth deck motion
  • Vision-based scanning to locate tips and labware
  • Sense of touch embedded into each channel

Agnostic Pipetting: Any Liquid, Any Volume

For years, liquid handlers have struggled with transferring liquids of varying viscosities and surface tensions due to time-consuming liquid class optimization. Finally, Formulatrix has developed a liquid handler that automates this process.

The FLO i8 PD effortlessly handles a wide range of liquids, from aqueous solutions to highly viscous fluids up to 100 cP, as well as volatile liquids, minimizing sample loss and contamination. The positive displacement tips allow users to pipette virtually any liquid in any volume without needing to program liquid classes.

A Liquid Handler That Optimizes Pipetting So You Don't Have To

Our liquid handler with 8 independently spanning channels simplifies experimental design, setup, and execution. The hardware offers the flexibility to handle any labware or liquid you throw at it, and the intuitive software makes it easy to define your workflow. With real-time progress monitoring, intelligent channels and tips, and positive displacement precision, the FLO i8 PD will be the lab partner you can't live without.

 Our Clients Include

Design Your Experiment in Minutes

The FLO i8 PD liquid handler breaks the mold of traditional systems with its intuitive, user-friendly interface and intelligent design. The UI makes even complex workflows straightforward, offering both drag-and-drop transfer mapping and the option to import a .csv worklist.

By designing a system that combines gold-standard pipetting hardware with intelligent sensing, we’ve reduced protocol creation to just one step: design your protocol. FLO i8 PD handles everything from simple liquid transfers to complex tasks you still perform manually, increasing experimental fidelity while reducing bench time.

With the FLO i8 PD, Formulatrix empowers efficient, reproducible research to drive scientific discovery. The system is designed to be so user-friendly that anyone in your lab can quickly become a power user.

Dynamic Liquid Level Detection and Tracking

The FLO i8 PD takes liquid level detection and tracking to the next level with sensors that enable dynamic liquid level tracking without prior definition of labware well profiles. Scientists can focus on their experiments instead of programming surface positions and complex labware parameters.

Don’t Stress Over Well Geometry

Tip touch sensors can find the bottom and sides of each well, so you don’t need to program the specific geometry of your labware.

The pipette touch sensors also facilitate best-in-class error management and safety by detecting collisions with obstructions and halting motion. Researchers can simply remove the obstruction, and the FLO i8 PD will continue from where it left off.

Simplify Setup with Vision-Based Deck Scanning

The FLO i8 PD liquid handler features a vision system with automatic tip and labware detection. Before each run, the camera scans the deck to confirm labware placement and verify that there are sufficient tips for the protocol. It identifies the size, number, and location of tips so users never have to rearrange tip caddies.

This functionality simplifies setup and reduces the risk of user error, allowing researchers to focus on more critical tasks.

Contamination Control

For contamination-sensitive workflows, the FLO i8 PD offers a range of add-on options to protect your samples at every stage of operation. 

UV Decontamination Module

The UV decontamination module irradiates the full deck surface with integrated UVC LEDs to mitigate biological contaminants between runs. UVC exposure reduces microbial contamination, degrades nucleic acids, and inactivates nucleases. Internal validation demonstrates >90% reduction in DNA after 10 minutes of exposure. 
 
The module is designed with both user and experiment safety in mind. The upgrade kit includes UV-compatible windows and a mechanical safety interlock preventing UVC exposure to the user. The UV cycle is triggered from the FLO i8 software and will only activate when no protocol is running.

FLO V3 UV Side
FLO V3 + HEPA V2.281 (1)

HEPA Filtration Module

The optional HEPA filtration module maintains positive pressure within the instrument enclosure, limiting ingress of airborne contaminants during operation. A replaceable HEPA H14 filter continuously removes bacterial and fungal particulates from incoming air, maintaining an internal environment that is consistent with ISO Class 7 cleanroom particle counts. Air is circulated at up to 2.2 m³/min at full fan speed.

Sterile Tips

For cell culture, sterility testing, and other contamination-sensitive applications, the FLO i8 PD supports ethylene oxide (EtO)-sterilized tips. 

Publications

Citations: 3 Product: FLO i8® PD
Bathe et al., 2026 |ACS Applied Materials and Interfaces |Link
Nucleic acid nanoparticles NANPs fabricated by using DNA origami are an emerging delivery vector for nucleic acid therapeutics Despite their advantages over other nanomaterials that include controlled spatial presentation of targeting ligands such as lipids and sugars understanding their cell targeting and uptake mechanisms remains limited Here we investigated NANP ...More |Related Solutions: FLO i8® PD
Kanappe et al., 2025 |Bioconjugate Chemistry |Link
Nucleic acid nanoparticles NANPs fabricated by using the DNA origami method have broad utility in materials science and bioengineering Their site-specific heterovalent functionalization with secondary molecules such as proteins or fluorophores is a unique feature of this technology that drives its utility Currently however there are few chemistries that enable ...More |Related Solutions: FLO i8® PD
Ofoegbu et al., 2024 |ACS NANO |Link
Nucleic acid nanoparticles NANPs are increasingly used in preclinical investigations as delivery vectors Tools that can characterize assembly and assess quality will accelerate their development and clinical translation Standard techniques used to characterize NANPs like gel electrophoresis lack the resolution for precise characterization Here we introduce the use of charge ...More |Related Solutions: FLO i8® PD

Resources