Microscale TFF with µPULSE: A Novel Solution for Lab-Scale Concentration, Buffer Exchange, and Desalting



In this presentation, we will present a novel way of concentrating samples and performing buffer exchange using the µPULSE - TFF System. The instrument is a fully automated, walk away system that uses miniaturized tangential flow filtration (TFF).


Walk-Away System:
Set your desired parameters and let the system do 95% of the process automatically until it is time to collect your sample; Remotely monitor via a web-based application.

Permeate flow rate up to 2.5x faster than centrifuges with dead-end filters.

Scalable Process:
Whether you are trying to scale up or down, µPULSE allows you to control all the parameters of an industrial TFF, at the research scale.

Wide Range of Operating Volumes:
Starting volumes between 1 and 100 mL final volume as low as 0.5 mL up to 250 mL of buffer exchange.

Lowest Hold-up Volume in the Industry:
Our patent-pending pump design offers just 0.65 mL of hold-up volume. Up to 100% hold-up recovery with automated recovery options.

Easy Maintenance:
All components in the fluid path are disposable consumables.

The µPULSE consumable chips can be cleaned in place for re-use up to 300 mL of permeate (sample dependent).

Nicholas (Cole) McKnight

About the Speaker:

Cole McKnight is the product manager for the µPULSE product line. He has been working to create lab automation technology with FORMULATRIX since 2020. His training is in mechanical engineering and product design with past experience designing 3D bioprinting technology. At FORMULATRIX, he manages engineering R&D and instrument/consumables production and facilitates sales, marketing, and customer support.