Publications

@article{noKey,

title = {Solution-Based Indirect Affinity Selection Mass Spectrometry—A General Tool For High-Throughput Screening Of Pharmaceutical Compound Libraries},

author = {O'Connell, Thomas N., Ramsay, Jason},

url = {https://pubs.acs.org/doi/10.1021/ac500938y},

doi = {https://doi.org/10.1021/ac500938y},

year  = {2014},

date = {2014-01-01},

abstract = {We show here that an automated solution-based affinity selection mass spectrometry (ASMS) system can be built exclusively from commercially available parts. The value of this technology lies in the throughput (∼1 × 105 compounds/day) coupled with a low hit rate. The system, being a binding assay, requires little development time yielding a fast timeline between target availability and hit identification. In addition, the use of exact mass simplifies the hit identification. We demonstrate this system using carbonic anhydrase as the target and a library of 144,000 proprietary compounds.},

keywords = {MANTIS},

pubstate = {published},

tppubtype = {article}

}