CELLMATICTM
CELLMATICTM
Automated Cell Culture
Scalable automation solutions ranging from feeding only systems to fully walk-away cell culture.
Built for Next-Gen Cell Culture
The Cellmatic is a fully automated cell culture system that handles your entire cell culture workflow continuously, from feeding and imaging to passaging and plating, without manual intervention. Define your protocol, load your cells, and walk away. The system manages the rest, around the clock, with consistency and reproducibility across every run.
Designed for everything from routine cell line maintenance to complex, month-long iPSC differentiation protocols, the Cellmatic scales to your throughput and adapts to your workflow.
Truly Walk-Away Cell Culture
Load your cells, define your protocol, and step back — the system runs 24/7, unattended
Many Cell Lines in Parallel
Dynamic and versatile scheduler with flexible reagent handling supports 50+ cell lines in culture at once
Built to Stay Sterile
HEPA filtration, positive pressure access points, and hydrogen peroxide vapor sterilization
Key Features
Fully Automated Cell Culture Workflow: Automate the entire cell culture process, including feeding, splitting, expansion, plating, and differentiation, freeing researchers to focus on science instead of manual execution.
High-Capacity Plate Handling: Each Incubator can support up to 200 SBS-format plates (1- to 384-well formats), enabling parallel processing of multiple cell lines and high-throughput experiments simultaneously.
Intelligent Scheduling and Parallel Processing: An advanced scheduler allows multiple users and protocols to run simultaneously, automatically interweaving tasks without scripting or programming.
Versatile Application Support: Supports stem cell differentiation, cell line development, high-throughput plating, permeability assays, and more — all on a single platform.
Smart Liquid Handling with Minimal Waste: Each Cold Dispense unit can support 5 media solutions in a sterile, refrigerated environment. Low dead volumes (500 µL) and reusable tips minimize reagent waste and running cost.
A Plate Storage Rack Housed in the Incubator
Integrated Cold Storage System: Provides robotic-access refrigerated storage for up to 96 SBS deep-well blocks, supporting large-scale reagent management in automated workflows.
Automated Labware Handling with Stack®: The Integrated Stack robotic arm moves plates and labware between subsystems inside the sterile enclosure, coordinated automatically by the Cellmatic scheduler, eliminating manual handling and reducing contamination risk.
Advanced Environmental and Contamination Control: HEPA filtration, hydrogen peroxide vapor sterilization, UV, and fully enclosed, CO₂, temperature, and humidity controlled Incubators maintain optimal, sterile growth conditions throughout operation.
Intuitive, Web-Based Software: User-friendly, no-code interface with real-time monitoring, scheduling, and data export. Access the system and receive alerts from anywhere via web-based software.
Which Cellmatic is Right for Your Lab?
Cellmatic Feeding System
Automates media exchanges in SBS plates
- Fully Enclosed, HEPA-filtered, Sterile Enclosure
- Reagent Exchanger (RX)
- Cellmatic Incubator (200 Plate Capacity)
- Cellmatic Cold Store
- Robotic Integration
- Cellmatic Controlling Software and Scheduler
Option add-ons
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Confluency Imager
-
Additional Incubator
-
BSC2 Enclosure for RX
-
Media Warmer
Full Cellmatic System
Complete 24/7 passaging and feeding of cells
-
Everything in the Feeding System
-
Media Warmer
-
Confluency Imager
- Labware Storage
Option add-ons
- BSC2 Enclosure for RX and FLO i8 PD
- Additional Incubator
- Centrifuge
- Capper/Decapper
Custom Integrations Available
From deep-freeze/thaw workflows enabled through third-party device integration to broader automation customization, the Cellmatic platform can be tailored to fit your laboratory’s specific process needs. In addition to standard configurations, custom integrations are available to support unique applications, specialized instruments, and evolving automation requirements.
Our team works with labs to adapt the system around their workflow requirements, helping create an automation solution that fits today’s needs while supporting future expansion.
Full Cellmatic — Deep Dive
Focus on Your Research. Let Cellmatic Handle the Rest
The Cellmatic system executes feeding, splitting, and plate handling continuously, 24/7, with no interruption. Load your starting cells, define your protocol, and walk away.
- Continuous 24/7 cell culture maintenance, freeing researchers to focus on science rather than manual upkeep
- Replace flasks with SBS-Format plates for simpler expansion and parallel handling of multiple cell lines
- Flexible storage capacity to match your needs. Start with a single 200 plate capacity Incubator, or add more as your throughput increases; your choice of plate density from single-well up to 384-well
- Define cell maintenance and assay plate schedules through a single no-code scheduling interface, adaptable to any cell culture application or protocol
- Web-based access from anywhere, with email and text alerts for real-time system notifications
Maintain Several Cell Lines with Intelligent Scheduling
The Cellmatic scheduler allows multiple users and groups to run protocols for different cell lines simultaneously. The scheduling automatically interweaves tasks to maximize the throughput without scripting, programming, or manual coordination required from the end user.
Versatile for a Broad Range of Scientific Workflows
Stem Cell
Differentiation
Automate week and month long protocols with thoughtful management of expensive reagents
Cell Line
Development
Pick colonies and propagate forward
from 384- and 96-well plates
Routine Maintenance and
Expansion
Continuously feed, image, and passage cell lines
with extensive data record keeping
Multi-well Plating
for HT Screens
Dispense cells into 384- and 96-well plates at user defined cell number
Permeability Assays with
Transwell Plates
Feed and culture cells in transwell plates
for your permeability assays
Immunology Studies with
PBMCs
Differentiate and mature blood cells for
immunological assays
Save Time and Reagents with Smart Liquid Handling
The system supports a wide range of reagents across two dedicated refrigerated units. The Cellmatic Cold Dispense stores bulk reagents in up to five 1 L bottles or 5 L media bags and automatically dispenses them into reservoirs directly within the refrigerated chamber, eliminating long tubing runs and the need to prime expensive reagents. The Cellmatic Cold Store provides cold storage for specialized reagents held in 96 deep-well blocks; when needed, these are automatically added to the base media to prepare the complete culture reagent on demand. Dispensed media is warmed before use with your cell culture plates. With capacity for up to 3 weeks of media storage and on-demand premixing for reagents with short expiration dates, the system runs extended workflows with minimal user intervention.
Precise, Enclosed Labware Handling with the Formulatrix Stack®
The Formulatrix Stack handles all labware movement within the Cellmatic, transferring cell plates, reagent troughs, and tips between the Incubator, Reagent Exchanger (RX), FLO i8 PD, and confluency imager entirely within the sterile enclosure. Every transfer is coordinated automatically by the Cellmatic scheduler, with no user intervention required between steps. The Stack's enclosed arm architecture ensures consistent, spill-free handling of large-volume liquid troughs and delicate cell plates alike, maintaining the sterility of the system throughout every run.
Advanced Technology Integrated into Every Subsystem
- 200-plates (multiple Incubators can be integrated together) with CO₂, temperature, and humidity controls
- 4°C refrigerated storage across two unit types: the Cellmatic Cold Dispense (up to 5 × 5 L bulk media bags) and the Cellmatic Cold Store (specialized reagents in 96 deep-well blocks), scalable with multiple units for up to 3 weeks of uninterrupted operation
- 8-channel liquid handler (FLO i8 PD), with independent z-axis control, dynamic liquid level detection, tilting deck, and choice of tip reuse or disposal
- RX, the automated plate washer, for media exchanges and high-throughput cell plating into multi-well plates
- Confluency imager capturing entire 96-well plate images in under 3 minutes
- Formulatrix Stack manages all labware transfers between subsystems, requiring no manual intervention
- Tightly controlled environment to reduce contamination — HEPA filters throughout, with access points maintained under positive air pressure
- Puroxia hydrogen peroxide vapor generator enabling full system sterilization
Efficient Cell Plating and Feeding with RX - Reduce Cost, Waste, and Time
The RX is the automated plate washer built into the Cellmatic system. Reusable nozzles aspirate spent media and gently dispense fresh, warmed media, processing a full 96-well plate in under one minute. Optimized for delicate cells, the RX also plates cells into 96- and 384-well plates for assay generation.
- Excellent cell plating CVs by continually stirring the cell suspension during dispensing
- Improved cell viability through non-contact, sidewall dispensing
- Full 96-well plate aspirated and dispensed in under one minute
- Compatible with 1-, 4-, 8-, 96-, 384-well plates; optional configuration to support 6-well plates
- Low dead volume of <5 µL/well in a 96-well plate
- Reduce contamination risk with automated lidding and delidding
Media Exchange in a 1-well Plate with Nozzle Cleaning
Media Exchange in a 96-well Plate
Need to Expand Cell Lines? Let the Cellmatic Handle It.
Load your starting cells, define the target cell number, and step back. The system handles the expansion automatically over the following days or weeks. The system uses one-well SBS format plates for cell expansion instead of flasks. It can output one well plate of expanded cells, pool multiple plates into a reservoir, or plate into high-density plates, depending on your needs. Run multiple cell line expansions in parallel, unattended.
Intuitive, Web-Based Software Designed Specifically for Cell Culture
Rather than scripting step by step aspirate and dispense sequences, users define the outcomes they want, specifying the trigger for splitting, imaging intervals, and passage ratio. The intuitive scheduler automatically interweaves all user requests. Results and analysis tools are displayed in a clear and structured layout with export tools for use in your own downstream analysis. Diagnostic routines run daily to confirm proper system operation.
Purpose-Built for Stem Cell Differentiation
Running a 30- to 60-day stem cell differentiation protocol? The Cellmatic handles your stem cells with precision and care. The 8-channel liquid handler manages growth factor additions on user-specified schedules. Phenotypic feedback — such as dendrite length from the high-resolution imager — can be used to direct protocols automatically. Cells are gently handled with minimal vibration throughout, and sidewall dispensing is used for all reagent additions. Protocols can be modified at any time, giving you full control. Protocol progress and results are visualized in the software dashboard throughout the run.
iPSCs grown in culture utilizing StemFlex medium and clump passaging with ReLeSR for dissociation
Cellmatic Feeding System — Deep Dive
Targeted Cell Culture Automation, Without the Full Footprint
The Cellmatic Feeding System is the entry point into Formulatrix cell culture automation. It automates the core of your cell culture routine: media exchange, incubation, and reagent storage, within a fully enclosed, HEPA-filtered sterile enclosure. With a smaller footprint and lower entry cost than the full Cellmatic, it is designed for labs that want to eliminate daily manual feeding and scale at their own pace.
Every Feeding System is upgradeable to the full Cellmatic, so the investment carries forward as your throughput grows.
What's Included — Standard Configuration
- Sterile Enclosure: Fully enclosed, HEPA-filtered environment maintaining contamination-free conditions around the clock
- Reagent Exchanger: Automated media exchanger for fast aspiration of spent media and gentle dispensing of fresh, warmed media. Learn More
- Cellmatic Incubator: 200-plate capacity with CO₂, temperature, and humidity control for continuous, uninterrupted culture. Learn More
- Cellmatic Cold Store: Refrigerated reagent and media storage supporting several weeks of unattended run time. Learn More
- Stack Robotic Integration: The Formulatrix Stack handles all labware transfers within the system. Learn More
- Cellmatic Software & Scheduler: Intuitive, web-based platform with no-code protocol setup
Expand Your Capabilities — Available Add-Ons
The Feeding System is built to grow with your lab. Optional modules can be added at purchase or retrofitted later:
- Media Warmer: Pre-warms media to physiological temperature before dispensing, reducing thermal stress on cells
- Confluency Imager: Scheduled daily imaging monitors cell density and triggers passage events based on confluency, not just a fixed schedule
- BSC2 Enclosure for RX: Adds biosafety as an additional layer for labs working with viral vectors or other BSL-2 materials
- Cellmatic Cold Dispense: Sterile, refrigerated dispensing for sensitive reagents that require cold-chain handling up to the point of use
- Additional Incubators: Expand plate capacity as the number of cell lines or assay plates in parallel increases
Flexible Automation for Your Budget and Workflow: See Which Components
Fit Your Lab
FLO i8 PD Liquid Handler: An 8-channel independent z-axis liquid handler with liquid level detection and a tilting deck. Handles cell mixing, suspension preparation, and precise dispensing with the flexibility to reuse or dispose of tips per protocol.
Learn More
Cellmatic Cold Store: Automated refrigerated storage for SBS plates, reservoirs, and labware. A motorized carousel positions labware for direct robotic retrieval — cold chain intact, no manual handling required.
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Cellmatic Incubator: High-capacity plate storage with precise CO₂, temperature, and humidity control. Dual robotic load ports and stationary plate storage keep cells undisturbed and workflows uninterrupted.
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Reagent Exchanger: Purpose-built for media exchange and cell plating across 1- to 384-well plates. Non-contact sidewall dispensing protects delicate cells while reusable tips and a 500 µL dead volume keep reagent waste to a minimum.
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Cellmatic Cold Dispense: On-demand reagent formulation inside a refrigerated, ISO 5-rated dispensing chamber. Automatically mixes and dispenses reagents into reservoirs, eliminating manual prep without breaking the cold chain.
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Puroxia: Compact, portable hydrogen peroxide vapor generator for reliable sterilization of biological equipment and automated workcells. Closed-loop concentration control ensures reproducible cycles at low reagent cost.
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