Design and Manage Experiments with Ease
The ROCK MAKER - Crystallization Software allows you to screen your proteins against sparse screens. The Screen Experiment Wizard makes experiment design a breeze - creating multiple screen experiments for one or more proteins takes less than a minute. Keep all your protein crystallization data in one place and follow your experiment results throughout the entire process.
Powerful Experiment Design
- Easy-to-use interface
- Most commonly used screens come pre-loaded
- Unique barcodes allow you to track your experiments from dispensing to imaging and scoring
Automatically Score Your Drops with MARCO
One bottleneck to protein crystallography is manually scoring those protein drop images, which is often very time-consuming and tedious. With the advent of machine learning has come the ability to have a computer algorithm analyze and score protein drop images. One such technology is the MAchine Recognition of Crystallization Outcomes or MARCO, which can score a 96 well- 1 drop plate in under 3 minutes, with an accuracy of ~94%. MARCO automatically provides a probability of a drop image being either a crystal, precipitate, clear, or other. MARCO is now integrated in ROCK MAKER and can automatically score your drops with just a few clicks.
One bottleneck to protein crystallography is manually scoring those protein drop images, which is often very time-consuming and tedious. With the advent of machine learning has come the ability to have a computer algorithm analyze and score protein drop images.
One such technology is the MAchine Recognition of Crystallization Outcomes or MARCO, which can score a 96 well- 1 drop plate in under 3 minutes, with an accuracy of ~94%. MARCO automatically provides a probability of a drop image being either a crystal, precipitate, clear, or other.
MARCO is now integrated in ROCK MAKER and can automatically score your drops with just a few clicks.
Reliable + Reproducible Protein Drop Setting
The NT8 - Drop Setter is a fast, nanoliter-volume liquid handler with drop dispensing capability for protein crystallization. The 8-tip head aspirates and dispenses drops from 10 nL to 1.5 μL. Reusable tips give you the option to dispose of tips after each dispense or reuse them to reduce costs and waste. Proportionally-Controlled Active Humidification minimizes sample evaporation and increases experiment reproducibility.
Dispense Drops for a Variety of Crystallization Experiments
- Hanging + Sitting Drop Experiments
- Lipidic Cubic Phase (LCP) Experiments
- Additive/Seeding Experiments
- Microbatch Experiments and more
Learn More About Your Protein Drops with Crystal Clear Imaging
Rock Imager is the most trusted imager for protein crystallography and is used by the top 10 pharmaceutical companies and many renowned academic centers worldwide.
The Academic Research Package includes the Rock Imager 1 (RI1) automated imaging system. The RI1 was designed specifically for protein crystallization and supports virtually every microplate format. This easy-to-use solution captures superior-quality images in a compact, benchtop unit.
The system images protein drops in both visible light and ultraviolet allowing researchers to discover conditions that grow crystals and determine if those are crystals are protein or not.
All Rock Imagers seamlessly integrate with the Rock Maker Crystallization Software keeping all your drop images and experiment data in one spot.
Dynamic and Efficient Image Viewing + Scoring
All the images taken by Rock Imager are collected by Rock Maker, wherein you can compare images and assign scores. Once you’ve found a crystal, you can measure its size and add notes directly to the image itself. Bring out details of your visible light and UV images using the leveling histogram or optically zoom in with a Region of Interest (ROI).
View + Score Images with Ease:
- Navigate through and score your images using your keyboard and customizable scoring schemas
- View up to four drops simultaneously or compare different inspections of the same drop
- View images with multiple modes including slideshow & full-screen
Analyze Your Data to Improve Future Experiment Design
Carry out an in-depth analysis of your results quickly using the powerful Search & Filter feature of Rock Maker. Based on previously performed experiments and user-defined criteria, you can make informed predictions about the most favorable conditions for crystallizing your protein of interest.
Built-In Data Analysis + Reporting Tools
- Use Search and Filter to mine your data to uncover trends based on a variety of parameters, helping you to continue your research efforts and focus in on conditions likely to grow bigger and better crystals
- Create and manipulate charts to visualize your experiment results
- Print various experiment reports for your lab notebooks
Zero in on the Optimal Crystallization Conditions
Got a hit? You can perform a quick multidimensional optimization of various conditions, varying concentrations and pHs of the ingredients along rows, columns, and/or quadrants within a plate. Rock Maker helps you effortlessly find the ideal conditions for crystal growth.