Liquid Handler


Application Notes

An Assessment of the Volumetric Performance of the MANTIS® Liquid Handler Using the Artel MVS® Multichannel Verification System

FORMULATRIX® and Artel present this application note in order to showcase the precision of the MANTIS® Liquid Handler, a novel solution designed to supplement traditional liquid handling platforms. By implementing the MANTIS, researchers can increase experimental reproducibility in genomics workflows that involve dispensing small volumes of valuable reagents with a high degree of precision. 

Rapid, Accurate and Flexible DNA Quantitation Using the QuantiFluor® dsDNA System on the MANTIS® Liquid Handler

Fluorescent dye-based quantitation systems are recommended for advanced downstream applications because of their sensitivity, target selectivity, cost, and ease of use. The QuantiFluor® dsDNA System can be used for quantitating dsDNA in single tubes as well as 96- and 384-well plates. Accuracy during repetitive pipetting of small volumes can be difficult and labor intensive with many opportunities for error and costly re-work. The MANTIS® Liquid Handler is a novel bench-top liquid handler that can meet many requirements for high-throughput reagent dispensing at a fraction of the cost of larger systems. For nucleic acid quantitation, the MANTIS accurately dispenses small volumes of the QuantiFluor® Dye working solution for reproducible quantitation results. In this application note, we demonstrate the compatibility of the MANTIS to quickly and accurately automate reagent handling of the QuantiFluor® dsDNA System for both 96- and 384-well plate formats. 

Cell dispensing in a high-content, primary neuron based, screening platform using the Mantis Liquid Handler

The Scripps Research Institute uses the Mantis as a precise, reliable, and robust solution for dispensing even the most sensitive primary neuronal cells in the generation of a high content screening platform. 

Automated Processing of the GlobalFiler® Express PCR Amplification Kit With the Formulatrix Mantis

This application note describes the use of the Mantis to dispense the Global Filer® Express Kit master mix to the amplification plate with treated buccal punches present.

Application Posters

Automation and Miniaturization of Low-Input RNA-SeqSample Prep Using Desktop Microfluidics

Miniaturization and scale-down of reagent and reaction volumes for low-inputRNA-Seq work flows enables researchers to work with low sample input and increased number sof samples. As the reaction volumes are reduced, accurate delivery of reagent volumes emerges as a critical step to maintain data quality and technical reproducibility.

We present results from miniaturization of the ClontechSMART-Seq® v4 Ultra® Low Input RNA Kit for Sequencing and Illumina Nextera® XT workflows for generation of high-qualityRNA-Seq samples using a compact desktop microfluidic dispensing technology.

High Throughput Large Scale Genotyping in Soybean Utilizing Novel Microfluidic Reagent Dispensing Technology

Recent advances in DNA marker/QTL (gene) discovery and marker detection technology have great impacts on crop improvement through marker-assisted selection. To discover and deploy the DNA markers in plant breeding programs, establishing low cost, high throughput, large scale and reliable and flexible marker genotyping platform is one of key factors. Implementing high-throughput workflows for SNP genotyping platforms such as TaqMan and KASP assays requires accurate dispensing of assay master mixes and reagents. Speed and accuracy are critical factors to achieve the desired assay performance while utilizing a workflow that minimizes reagent utilization to allow for large-scale studies.


Assuring Optimal Promega Assays Development by Design of Experiment Workflow and Mantis Dispenser

To facilitate assay development we employ a Design of Experiment approach during assay development. Design of Experiments (DoE) offers a systematic way of simultaneously evaluating multiple assay parameters and analyzing the resulting process outputs to optimize assay conditions with a minimum number of experiments

Computer Requirements
  • Computer OS :
    • Windows XP Home Edition SP3 32-bit
    • Windows 7 Home Basic 64-bit
    • Windows Vista 32-bit
  • One open USB port (USB 2.0 recommended, USB 3.0 supported)
  • Dual Core 1GHz processor
  • 1 GB RAM
  • 1 GB of Hard Drive space
  • 768 pixels vertical minimum screen resolution
Electrical Specifications
  • 110-240 V, 50-60 Hz, 50 W typical, 100 W max
Physical Dimensions - MANTIS® Liquid Handler
  • Width: 354 mm max (smaller without ACC or reagent holders)
  • Height Full Extension: 273 mm (not including pipette tip adapter)
  • Height No Extension: 172 mm (not including pipette tip adapter)
  • Depth: 212 mm
  • Weight: Approx. 5.2 kg (11.5 lbs)